Anionic Binding Site and 2,3-DPG Effect in Bovine Hemoglobin
نویسندگان
چکیده
منابع مشابه
Characterisation of a Binding Site for Anionic Phospholipids on Kcnq1
CHARACTERISATION OF A BINDING SITE FOR ANIONIC PHOSPHOLIPIDS ON KCNQ1 Alison M. Thomas, Stephen C. Harmer, Tapsi Khambra & Andrew Tinker From the Department of Medicine, University College London, 5 University Street, London, WC1E 6JJ, UK. Running Title: A PIP2 binding site on KCNQ1 * These authors contributed equally to this study Address correspondence to: Professor Andrew Tinker, Department ...
متن کاملCharacterization of a binding site for anionic phospholipids on KCNQ1.
The KCNQ family of potassium channels underlie a repolarizing K(+) current in the heart and the M-current in neurones. The assembly of KCNQ1 with KCNE1 generates the delayed rectifier current I(Ks) in the heart. Characteristically these channels are regulated via G(q/11)-coupled receptors and the inhibition seen after phospholipase C activation is now thought to occur from membrane phosphatidyl...
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Inwardly rectifying potassium (Kir) channels regulate multiple tissues. All Kir channels require interaction of phosphatidyl-4,5-bisphosphate (PIP2) at a crystallographically identified binding site, but an additional nonspecific secondary anionic phospholipid (PL(-)) is required to generate high PIP2 sensitivity of Kir2 channel gating. The PL(-)-binding site and mechanism are yet to be elucida...
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Haptoglobin forms a stable, irreversible complex with hemoglobin. The H chain of haptoglobin, which is the subunit that binds hemoglobin, shows strong sequence homology with the serine protease family. This raises the question of whether hemoglobin binds to the protease-like active site pocket of H chain as the protease inhibitors do with serine proteases. This question can be tested by binding...
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We studied thrombin binding to proliferating and confluent endothelial cells derived from bovine vascular endothelium. [125]thrombin was incubated with nonconfluent or confluent endothelial cells and both the total amount bound and the amount linked in a 77,000-dalton thrombin-cell complex were determined. Approximately 230,000 molecules of thrombin bound per cell in nonconfluent cultures compa...
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ژورنال
عنوان ژورنال: Biochemistry
سال: 1998
ISSN: 0006-2960,1520-4995
DOI: 10.1021/bi985059l